Endocrine Abstracts

Introduction: Many patients with diabetes experience high variability in glucose concentrations which is associated with a risk of hypoglycemia. The aim of this was to compare the predictive value of HbA1C, mean interstitial glucose (MIG), and glucose variability (GV) in the risk of hypoglycemia in patients with type 1 diabetes (T1D).Methods: Continuous glucose monitoring, using CGMS system, was performed in 130 T1D patients with diabetes duration of 17....

Background and objectives: Evaluate the impact of therapy with GLP-1 analogues (liraglutide) on glycemic control and weight in patients with type 2 diabetes and poor metabolic control.Material and methods: We conducted a retrospective observational study analyzing 67 patients with type 2 diabetes mellitus and BMI >30 kg/m2, over 6 months of treatment. We evaluated HbA1c and weight at 3 and 6 months, performing statistical analysis with SPS...

Introduction: Several studies suggest DHEA and DHEAS (DHEA(S)) are related to memory enhancement and a better performance under stress. An anti-cortisol action may contribute to those relations. We looked for a new level of evidence, by studying DHEA(S) and cortisol relations to working memory (WM) and distraction in humans also at the electrophysiological level.Subjects and methods: Twenty-eight healthy female volunteers (18–26 years old) were pres...

Introduction: Several studies reported DHEA relations to memory and cognition improvement. An anti-cortisol action may contribute to those relations. The effect of working memory (WM) on DHEA levels is unknown. We studied DHEA and cortisol reactivity in humans after a WM stimulus with simultaneous distraction.Subjects and methods: Twenty eight healthy female volunteers (18–26 years old) were presented a well-established auditory-visual distraction t...

Introduction: The final height of children with congenital adrenal hyperplasia (CAH) seems to be compromised. That can happen because of the disease itself or because an excessive dose of corticoids used during treatment. This work evaluates the final stature SDS of a group of patients with CAH and correlates it with 17-hydroxyprogesterone levels (17OHP) and corticoid dose at 10 years of age and at puberty onset.Methods: Selection of children with CAH di...

Introduction: Medullary thyroid carcinoma (MTC) is a rare form of thyroid cancer, making up about 3–5% of all cases. It is characterized by the synthesis and secretion of calcitonin (Ct). Measurement of Ct has low specificity but is a highly sensitive method for the detection of MTC. MTC with normal or only slightly elevated Ct is a rare occurrence and there are few such reports in the literature.Case report: A 61-year-old male patient was referred ...

AKT serine-threonine kinases are critical mediators of both growth and metabolic actions of insulin. AKT2 is believed to exert predominantly metabolic effects, while AKT1 has been more strongly implicated in growth. We have recently reported that the de novo AKT2 p.Glu17Lys mutation produces a sporadic syndrome of severe persistent hypoinsulinaemic hypoglycaemia associated with left-sided hemihypertrophy. Glucose requirements in affected patients are far lower than seen in hyp...

Introduction: Langerhans’ Cell Histiocytosis (LCH) is a rare disease, more common in children than in adults, resulting from aberrant proliferation of Langerhans’ cells, belonging to the monocyte–macrophage system.Case history: We present the case report of a 40-year-old man with a 16-year history of polyuria, polydipsia and tiredness. For 10 years he had perianal, groin, abdomen and scalp scarring, hyperpigementation along with follicles ...

Introduction: Primary hyperparathyroidism (PHP) results from an excessive secretion of parathyroid hormone (PTH), typically leading to hypercalcaemia. This disorder is more common than previously expected, since it is frequently diagnosed in asymptomatic patients.Objectives: To characterize a group of patients with PHP, in what concerns to: age, clinical presentation, biochemical and imaging evaluation, treatment and evolution.Pati...

Introduction: An insulin therapy protocol (ITP) was created during 2007 in our hospital by endocrinologists, internal physicians and nurses. The aim was to establish the basal-bolus therapy as the treatment for the non-critical diabetic in-patients in order to ease the management and lead a better glycemic control of these patients. A poster was presented to all the hospital departments in several meetings during 2008. This poster showed the way to calculate the initial insuli...